Epigenetics and neural stem cell commitment

Stem cell epigenetics: looking forward.

The integrity of tissues is maintained by adult stem cells during adulthood. However, recent work indicates that tissues often contain more than one population of stem cells that are located at distinct niches and display different behaviors, making the role of stem cells in tissue homeostasis far more complex than previously thought. Generally, each population of stem cells predominantly contr...

P70: Produce Neural Stem Cell from Neurosphere of Rat Adipose Derived Stem Cell

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The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine.

The transplantation of exogenous stem cells and the activation of endogenous neural stem and progenitor cells (NSPCs) are promising treatments for stroke. These cells can modulate intrinsic responses to ischemic injury and may even integrate directly into damaged neural networks. However, the neuroprotective and neural regenerative effects that can be mediated by these cells are limited and may...

Neuroinflammation on the Epigenetics of Neural Stem Cells

Chromatin-based epigenetics of adult subventricular zone neural stem cells

In specific regions of the adult mammalian brain, neural stem cells (NSCs) generate new neurons throughout life. Emerging evidence indicate that chromatin-based transcriptional regulation is a key epigenetic mechanism for the life-long function of adult NSCs. In the adult mouse brain, NSCs in the subventricular zone (SVZ) retain the ability to produce both neurons and glia for the life of the a...